Davis Okoye (Dwayne Johnson) has cared for an albino gorilla, George, since it was born, and the two have an unbreakable connection. This connection is put to the test however when George transitions into a massive beast due to a genetic experiment mishap. It is up to Davis to save the world from the havoc that his friend George becomes capable of, along with a few other monstrous creatures that were subject to the same kind transformation.